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Gestational DM Pathophysiology and Epidemiology
Gestational DM
Pathophysiology and Epidemiology
F. Hosseinpanah
Obesity Research Center
Research Institute for Endocrine sciences
Shahid Beheshti University
of Medical Sciences
January19,2012
Tehran
Outline
- Brief review of pathophysiology
- Risk factors of GDM
- Reported prevalence in Iran
- Trend of obesity in Iran
- Impact of new criteria on prevalence of GDM
- Conclusion
Early pregnancy
- Increased glucose-stimulated insulin secretion
- Unchanged or enhanced peripheral (muscle) insulin sensitivity
- Unchanged basal hepatic glucose production
- Normal or slightly improved glucose tolerance
- Normal sensitivity to the blood glucose–lowering effect of exogenously administered insulin
